Author

I. Chiu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

A. C. Wells· 1 shared A. I. Lim· 1 shared A. J. Walker· 1 shared A. Liu· 1 shared A. Sheen· 1 shared A. Tabet· 1 shared B. A. Johns· 1 shared B. Smith· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperImmunology

A. C. Wells

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis

M. Marin-Rodero, E. Cintado, A. J. Walker, T. Jayewickreme, F. A. de Pinho-Ribeiro, Q. Richardson, R. Jackson, I. Chiu, C. Benoist, J. L. Trejo, b. stevens, D. Mathis

The paper identifies a unique population of regulatory T cells in the murine meninges that maintain brain homeostasis by suppressing interferon-gamma-producing lymphocytes and preventing hippocampal damage.

bioRxiv · Jun 17, 2024Immunology

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Y. Dong, B. A. Johns, L. Ruan, M. Zeineldin, A. Liu, S. Raychaudhuri, I. Chiu, J. Zhu, B. Smith, N. Zhao, P. Searson, S. Watanabe, M. Donowitz, T. C. Larman, R. Li

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

Science Advances · Apr 5, 2024Peer-reviewedCell Biology

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota

W. Kulalert, A. C. Wells, V. M. Link, A. I. Lim, N. Bouladoux, M. Nagai, O. J. Harrison, O. Kamenyeva, J. Kabat, M. Enamorado, I. Chiu, Y. Belkaid

This study identifies a neuroimmune CGRP-RAMP1 axis that modulates cutaneous adaptive immunity to the microbiota by constraining Type 17 responses and limiting T cell activation.

bioRxiv · Dec 26, 2023 · PreprintImmunology

Reprogramming brain immunosurveillance with engineered cytokines

A. Tabet, Y. Agarwal, J. Stinson, C. Apra, V. Will, M. Manthey, N. Momin, A. Sheen, M. Murdock, L. Santollani, L.-H. Tsai, I. Chiu, S. E. Lawler, D. J. Irvine, K. D. Wittrup, P. Anikeeva

This study shows engineered cytokines can reprogram brain immunosurveillance by extending their residence time in the brain using alum scaffolds, delaying tumor progression in mouse models.

bioRxiv · Jun 21, 2022 · PreprintBioengineering

On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis

F. M. Key, V. D. Khadka, C. Romo-Gonzalez, K. J. Blake, L. Deng, T. C. Lynn, J. C. M. Lee, I. Chiu, M. T. Garcia, T. D. Lieberman

This study tracks S. aureus adaptation during AD treatment, finding de novo mutations and capD gene selection linked to disease severity.

bioRxiv · Mar 24, 2021Microbiology

Allergen-induced dendritic cell migration is controlled through Substance P release by sensory neurons

P. A. Aderhold, Z. N. A. Dewan, C. Perner, C. H. Flayer, X. Zhu, T. Voisin, R. B. Camire, I. Chiu, O. A. Chow, C. L. Sokol

This study shows allergen-activated sensory neurons release Substance P, which activates CD301b+ dendritic cells to migrate to lymph nodes and initiate Th2 responses.

bioRxiv · Jun 5, 2020 · PreprintImmunology