Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer.
Santiago Panesso-Gómez, Alexander J. Cole, Alyssa M. Wield, Vivian I. Anyaeche, Jaynish S. Shah, Qi Jiang, Tonge Ebai, Allison C. Sharrow, George C. Tseng, Euisik Yoon, Daniel D. Brown, Amanda M. Clark, Scott D. Larsen, Ian Eder, David M. Gau, , Ronald J. Buckanovich
This study identifies the MRTFA/SRF pathway as a regulator of quiescence in cancer and shows that inhibiting it induces quiescence and reduces tumor growth.
bioRxiv · Nov 15, 2024 · PreprintCancer Biology