David M. Gau

Survivin as a Multifaceted Oncogenic Driver and Therapeutic Target in Renal Cell Carcinoma

This study identifies survivin as a key oncogenic driver in renal cell carcinoma, showing its roles in cell cycle, migration, and mitochondrial function, and suggests it as a therapeutic target.

Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate

This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.

Microplastics inhibit macrophage bioenergetics impairing homeostatic function and immune responsiveness

This study shows that microplastics impair macrophage bioenergetics and immune function, reducing antigen presentation and increasing disease susceptibility.

Profilin-1 Promotes Chromophobe Renal Cell Carcinoma Malignancy

This study identifies Profilin-1 as a driver of chromophobe renal cell carcinoma progression by promoting proliferation, invasion, and resistance to oxidative stress.

Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma

This study shows that a small molecule Pfn1 inhibitor reduces tumor angiogenesis in renal cell carcinoma by targeting endothelial cell Pfn1.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer.

This study identifies the MRTFA/SRF pathway as a regulator of quiescence in cancer and shows that inhibiting it induces quiescence and reduces tumor growth.