Author

Ian Eder

University of PittsburghORCID 0000-0001-7111-9752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Partha Sarathi RoyiD· 3 shared David M. GauiD· 2 shared Jianhua Luo· 2 shared Silvia LiuiD· 2 shared Abrahim Kashkoush· 1 shared Adrian V. LeeiD· 1 shared Alexander J. ColeiD· 1 shared Allison C. SharrowiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

Partha Sarathi RoyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast Cancer

Ian Eder, Masoumeh Baghaei, Sudeep K. Maurya, Virginia Yu, Elijah Wilson, Abrahim Kashkoush, Jia-Jin Liu, Silvia Liu, Jianhua Luo, Walter J. Storkus, Partha Sarathi Roy

This paper shows that reducing Profilin-1 in breast cancer cells triggers genomic instability and activates the cGAS-STING pathway, enhancing T cell-mediated anti-tumor immunity and leading to tumor regression.

bioRxiv · Jun 10, 2026 · PreprintCancer Biology

Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate

Andrew Orenberg, Michael J. Chirumbolo, Ian Eder, Jia-Jun Liu, Silvia Liu, David M. Gau, Yubo Tang, Klemens Rottner, Jianhua Luo, Gerald R. V. Hammond, Partha Roy

This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.

Journal of Cell Science · May 21, 2026Peer-reviewedCell Biology

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer.

Santiago Panesso-Gómez, Alexander J. Cole, Alyssa M. Wield, Vivian I. Anyaeche, Jaynish S. Shah, Qi Jiang, Tonge Ebai, Allison C. Sharrow, George C. Tseng, Euisik Yoon, Daniel D. Brown, Amanda M. Clark, Scott D. Larsen, Ian Eder, David M. Gau, , Ronald J. Buckanovich

This study identifies the MRTFA/SRF pathway as a regulator of quiescence in cancer and shows that inhibiting it induces quiescence and reduces tumor growth.

bioRxiv · Nov 15, 2024 · PreprintCancer Biology