Rapid optimization of protein function in mammalian cells via microbe-independent deep assembly and screening
Yan Wu, Pengli Wang, Lan Xiang Liu, Chao Gao, Qin Qin, Matt Hageman, Thomas A. Kirkland, Yichi Su, Michael Z. Lin
This paper introduces MIDAS, a method to rapidly optimize protein function in mammalian cells, demonstrating its effectiveness in improving a neurotransmitter indicator.
bioRxiv · Mar 30, 2025 · PreprintBioengineering