Yukun Alex Hao

Measuring neuronal input-output operations in vivo with random access projection microscopy

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

Efficient biological design via genomic in-context learning

This paper demonstrates that in-context learning in the genome language model Evo 2 enables efficient biological sequence design without additional training.

Ultrasensitive voltage imaging reveals distinct electrical microdomains in neurons

The paper develops a genetically encoded voltage indicator to measure subthreshold voltage dynamics in neurons, revealing electrical diversity and local computation.

Intrinsic space-time couplings governing multi-scale cortical dynamics

This study introduces a new microscopy technique to track neocortical activity with high spatial and temporal resolution, revealing fundamental dynamical elements and their properties across different neural activity regimes.

Causal and directional elements of global brain dynamics

The paper identifies directional elements in brain dynamics that encode causal control hierarchies and show robustness to neural state manipulations.

A deep learning framework for automated and generalized synaptic event analysis

This paper introduces miniML, a deep learning framework for automated synaptic event detection that outperforms existing methods in precision and recall across diverse preparations and species.

BIFROST: a method for registering diverse imagingdatasets of the Drosophila brain

BIFROST registers diverse Drosophila brain imaging datasets into a common anatomical space, enabling cross-experiment and cross-modality comparisons with sub-10 micron precision.

Improving positively tuned voltage indicators for faster kinetics and higher contrast

The paper improves positively tuned voltage indicators by enhancing their kinetics and contrast for better spike detection.

Mapping the Neural Dynamics of Locomotion across the Drosophila Brain

The paper maps neural activity associated with walking across the entire Drosophila brain, identifying global and clustered signals linked to locomotion and future movement anticipation.

A positively tuned voltage indicator reveals electrical correlates of calcium activity in the brain

This paper introduces positively tuned GEVIs that enhance spike detection in vivo with standard imaging systems, offering higher temporal resolution than calcium indicators.