Richard H. Roth

This study shows that Sall3 is essential for forming GABApre synapses on Ia afferents, and its loss disrupts motor behavior by impairing presynaptic inhibition.

This paper introduces a color-neutral and reversible tissue transparency method that enables longitudinal deep-tissue imaging in live mice with high spatiotemporal resolution.

This study shows that motor learning dynamically regulates axonal boutons in the corticostriatal pathway, increasing reward-selective boutons and eliminating un-rewarded ones.

The paper identifies region-specific transcriptomic changes in motor cortex and striatum during motor learning using single-cell RNA sequencing and genetic labeling.

The paper identifies thalamic neurons that integrate signals from the basal ganglia and cerebellum during motor learning and shows their critical role in motor task execution.

This study shows that preventing oligodendrocyte maturation during adolescence reduces myelination and preserves experience-dependent plasticity in adult visual cortex.

The paper improves positively tuned voltage indicators by enhancing their kinetics and contrast for better spike detection.

This paper introduces positively tuned GEVIs that enhance spike detection in vivo with standard imaging systems, offering higher temporal resolution than calcium indicators.

This study identifies synaptic plasticity in motor engram neurons during motor learning, showing increased spine density and connectivity to striatal neurons.

The paper develops tools to track synaptic plasticity in vivo by imaging endogenous AMPA receptors and generates a detailed spatiotemporal map of synaptic changes during behavior.

This paper introduces TKIT, a CRISPR/Cas9 method for precise genomic knock-in in neurons, achieving up to 42% efficiency in mouse neurons and demonstrating its use in rat neurons for visualizing endogenous proteins.