Author

Yan Wu

Stanford UniversityORCID 0000-0003-2596-1943Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yan Wu7 papers · Syracuse University

Biology Disciplines

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Bioengineering· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Michael Z. LiniD· 2 shared Thomas A. KirklandiD· 2 shared Yichi SuiD· 2 shared Alex InagueiD· 1 shared Chao GaoiD· 1 shared Fangzhu ZhaoiD· 1 shared James A. OlzmanniD· 1 shared James A. WellsiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Michael Z. LinORCID

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3 papers

Recent·Most cited

BioengineeringProceedings of the National Academy of SciencesPeer-reviewedSep 30, 2026

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells

Fangzhu Zhao, Alex Inague, Trenton M. Peters-Clarke…·James A. Wells

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

1 citationtop 4%

humanexperimental assay

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NeurosciencebioRxivPreprintJan 23, 2026

Bright calcium-modulated bioluminescent indicators for activity imaging and red photon-assisted synaptic transmission

Yufeng Zhao, Montserrat Porta-de-la-Riva, Sungmoo Lee…·Michael Z. Lin

The paper introduces improved bioluminescent calcium sensors and opsin variants for non-invasive imaging and synaptic transmission in C. elegans.

DOI 10.64898/2026.01.20.700092

C. elegansexperimental assay

𝕏 PostBluesky

BioengineeringbioRxivPreprintMar 30, 2025

Rapid optimization of protein function in mammalian cells via microbe-independent deep assembly and screening

Yan Wu, Pengli Wang, Lan Xiang Liu…·Michael Z. Lin

This paper introduces MIDAS, a method to rapidly optimize protein function in mammalian cells, demonstrating its effectiveness in improving a neurotransmitter indicator.

1 citation

humanproteomics

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