Drug tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms
Maria Davern, Cole J. Turner, Daryl Griffin, Lara Bencsics, Brenda C. Chan, Jasmine Yun-Tong Kung, Michael Olson, Cheyanne Walker-Williams, Shaili Soni, Leah Krotee, Michael Yorsz, Gabriella Antonellis, Patrick Hall Lizotte, Cloud Peter Paweletz, Jeremy A. Ryan, , Anthony G. Letai
This study identifies common survival mechanisms between drug-tolerant persisters and immunotherapy persisters, showing they share reduced mitochondrial apoptotic sensitivity and cross-resistance to therapies.
Cell Death and Differentiation · Dec 26, 2025Peer-reviewedCancer Biology