Senescent Activated Naive B Cells Promote Anti-Citrullinated Antigen T Cell Responses and the Transition to Clinical Rheumatoid Arthritis
Xiaohao Wu, Mengrui Zhang, Jae‐Seung Moon, Eun Kyung Song, Joshua C Abrams, Laura S. van Dam, Orr Sharpe, Marie L. Feser, Laurie K. Moss, Peggy Pui-Kay Ho, Melanie H. Smith, Laura H Donlin, Jane Hoyt Buckner, Eddie A. James, Gary S. Firestein, , William H. Robinson
This study identifies senescent activated naive B cells in ACPA+ individuals that promote anti-citrullinated antigen T cell responses and drive progression to clinical RA.
bioRxiv · Oct 14, 2025 · PreprintImmunology