Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation
Chloé I. Charendoff, Félix V. Louchez, Yongzheng Wu, Lee Dolat, Guillaume Velasco, Stéphanie Perrinet, Adrián Gabriel Torres, Laure Blanchet, Magalie Duchateau, Quentin Giai Gianetto, Mariette Matondo, Laurence Del Maestro, Slimane Ait‐Si‐Ali, Frédéric Bonhomme, Gaël A. Millot, , Agathe Subtil
This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.
eLife · Sep 14, 2026Peer-reviewedCell Biology