The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
Marla E. Tharp, Claudia Z. Han, Maya Talukdar, Christopher D. Balak, Conor Fitzpatrick, Carolyn O’Connor, Sebastian Preißl, Justin Buchanan, Alexi Nott, Laure Escoubet, Konstantinos Mavrommatis, Mihir Gupta, Marc S. Schwartz, Sang U Hoi, Pamela S. Jones, , David C. Page
The paper identifies sex differences in microglial inflammatory responses in glioblastoma, showing that genes on the inactive X chromosome drive these differences.
bioRxiv · Jun 6, 2024 · PreprintGenomics