Author
University of California San DiegoORCID 0000-0002-2285-5582Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Haley Jetter, Claudia Z. Han, Sarah D. Ackerman
The paper uses CRISPR/Cas9 to knockdown glycosylation genes in zebrafish, revealing shared neurological dysregulation across CDG classes through RNA sequencing and behavioral assays.
bioRxiv · Oct 24, 2026 · PreprintNeuroscience
Siling Du, Feiya Ou, Antoine Drieu, Eric Z. Xu, Yumeng Cheng, Steffen E. Storck, Tornike Mamuladze, Jay Cao, Nora Abduljawad, Bishan Bhattarai, Justin Rustenhoven, Niall Mortimer, Simone Brioschi, Khai M. Nguyen, Patrick Fernandes Rodrigues, , Jonathan Kipnis
The paper identifies distinct transcriptional and epigenetic profiles of brain-engrafted monocyte-derived macrophages compared to microglia, showing their origin from peripheral blood and skull bone marrow.
Neuron · Mar 11, 2026Peer-reviewedImmunology
Marla E. Tharp, Claudia Z. Han, Maya Talukdar, Christopher D. Balak, Conor Fitzpatrick, Carolyn O’Connor, Sebastian Preißl, Justin Buchanan, Alexi Nott, Laure Escoubet, Konstantinos Mavrommatis, Mihir Gupta, Marc S. Schwartz, Sang U Hoi, Pamela S. Jones, , David C. Page
The paper identifies sex differences in microglial inflammatory responses in glioblastoma, showing that genes on the inactive X chromosome drive these differences.
bioRxiv · Jun 6, 2024 · PreprintGenomics
Isaac Shamie, Sascha H. C. Duttke, Karen Julie la Cour Karottki, Claudia Z. Han, Anders Holmgaard Hansen, Hooman Hefzi, Kai Xiong, Shangzhong Li, Samuel J. Roth, Jenhan Tao, Gyun Min Lee, Christopher K. Glass, Helene Faustrup Kildegaard, Christopher W. Benner, Nathan E. Lewis
The paper revises transcription start site annotations in Chinese hamster genes using experimental data to improve gene engineering and glycosylation in CHO cells.
NAR Genomics and Bioinformatics · Jun 23, 2021Peer-reviewedGenomics
Claudia Z. Han, Rick Z. Li, Emily A. Hansen, Hunter R. Bennett, Olivier Poirion, Justin Buchanan, Jean F. Challacombe, Bethany R. Fixsen, Samantha Trescott, Johannes C. M. Schlachetzki, Sebastian Preißl, Allen Wang, Carolyn O’Connor, Anna S. Warden, Shreya Shriram, , Nicole G. Coufal
This study defines age-specific brain environmental factors driving microglia phenotypes through transcriptomic and epigenomic analysis of human fetal and postnatal microglia.
bioRxiv · Jun 2, 2021 · PreprintGenomics
Alexi Nott, Inge R. Holtman, Nicole G. Coufal, Johannes C. M. Schlachetzki, Miao Yu, Rong Hu, Claudia Z. Han, Monique Pena, Jiayang Xiao, Yin Wu, Zahara Keulen, Martina P. Pasillas, Carolyn O’Connor, Simon T. Schafer, Zeyang Shen, , Christopher K. Glass
The paper identifies cell type-specific enhancer-promoter connectivity in the human brain and links these to disease risk variants in Alzheimer's and psychiatric disorders.
bioRxiv · Sep 22, 2019 · PreprintNeuroscience