Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.
Alexandra Kazanova, Jacqueline Sung, Nathalia Oliveira, Christina Gavino, Sherilyn Junelle Recinto, Hicham Bessaiah, Jessica Pei, Lindsay Burns, Willemein Miller, Morgane Brouillard-Galipeau, Lei Zhu, Lucia Guerra, Moustafa Nouh Elemeery, Adam MacDonald, Joël Lanoix, , Samantha Gruenheid
This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.
bioRxiv · Feb 25, 2024 · PreprintImmunology