Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity
Benjamin Segain, Ryan Conesa, Christina M. Rollings, Sofia Titah, Elise Paulin, Adeline Cozzani, Angélina Kasprowicz, Leila Mohammadnizad, Silvia Gaggero, Yasmine S. Touil, Ignacio Moraga, Bruno Quesnel, Rahul Roychoudhuri, Robert Eil, Linda V. Sinclair, , Suman Mitra
This study shows that chronic extracellular acidosis remodels lysosomes in CD8+ T cells, impairing their cytotoxicity by depleting granzyme B through vesicle release.
bioRxiv · Oct 27, 2026 · PreprintImmunology