Author

Ignacio Moraga

Institut Pasteur de LilleORCID 0000-0001-9909-0701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Jonathan Martínez‐FábregasiD· 2 shared Silvia GaggeroiD· 2 shared Suman MitraiD· 2 shared Adeline CozzaniiD· 1 shared Angélina Kasprowicz· 1 shared Benjamin SegainiD· 1 shared Bruno QuesneliD· 1 shared Carmen Molina-Parı́siD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Jonathan Martínez‐FábregasORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity

Benjamin Segain, Ryan Conesa, Christina M. Rollings, Sofia Titah, Elise Paulin, Adeline Cozzani, Angélina Kasprowicz, Leila Mohammadnizad, Silvia Gaggero, Yasmine S. Touil, Ignacio Moraga, Bruno Quesnel, Rahul Roychoudhuri, Robert Eil, Linda V. Sinclair, , Suman Mitra

This study shows that chronic extracellular acidosis remodels lysosomes in CD8+ T cells, impairing their cytotoxicity by depleting granzyme B through vesicle release.

bioRxiv · Oct 27, 2026 · PreprintImmunology

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders

Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martínez‐Fábregas, Maximillian Hafer, Paul K. Fyfe, Elizabeth Pöhler, Silvia Gaggero, Martín López‐García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-Parı́s, Ignacio Moraga

The paper investigates how differential STAT binding to receptor phospho-Tyr motifs influences cytokine responses, showing altered dynamics in autoimmune disorders like SLE.

eLife · Apr 19, 2021Peer-reviewedBioinformatics