Jonathan Martínez‐Fábregas

Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity

This study shows that chronic extracellular acidosis remodels lysosomes in CD8+ T cells, impairing their cytotoxicity by depleting granzyme B through vesicle release.

Asparagine endopeptidase promotes radioresistance in breast cancer through ATR pathway modulation

This study identifies AEP's role in promoting radioresistance in breast cancer by modulating the ATR pathway and PPP1R10 levels, showing AEP-high/ATR-low as a biomarker for radioresistant patients.

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders

The paper investigates how differential STAT binding to receptor phospho-Tyr motifs influences cytokine responses, showing altered dynamics in autoimmune disorders like SLE.