Author

Benjamin Segain

Centre National de la Recherche ScientifiqueORCID 0009-0009-2885-9531Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adeline CozzaniiD· 1 shared Angélina Kasprowicz· 1 shared Bruno QuesneliD· 1 shared Christina M. RollingsiD· 1 shared Elise Paulin· 1 shared Ignacio MoragaiD· 1 shared Jonathan Martínez‐FábregasiD· 1 shared Leila Mohammadnizad· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Adeline CozzaniORCID

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintOct 27, 2026

Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity

Benjamin Segain, Ryan Conesa, Christina M. Rollings…·Suman Mitra

This study shows that chronic extracellular acidosis remodels lysosomes in CD8+ T cells, impairing their cytotoxicity by depleting granzyme B through vesicle release.

DOI 10.64898/2026.10.21.760659

humanproteomics

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