Author

Bruno Quesnel

Centre National de la Recherche ScientifiqueORCID 0000-0002-6563-2709Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adeline CozzaniiD· 1 shared Angélina Kasprowicz· 1 shared Benjamin SegainiD· 1 shared Christina M. RollingsiD· 1 shared Elise Paulin· 1 shared Ignacio MoragaiD· 1 shared Jonathan Martínez‐FábregasiD· 1 shared Leila Mohammadnizad· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Adeline CozzaniORCID

Mutual co-authors in cluster

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1 paper

Recent·Most cited

Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity

Benjamin Segain, Ryan Conesa, Christina M. Rollings, Sofia Titah, Elise Paulin, Adeline Cozzani, Angélina Kasprowicz, Leila Mohammadnizad, Silvia Gaggero, Yasmine S. Touil, Ignacio Moraga, Bruno Quesnel, Rahul Roychoudhuri, Robert Eil, Linda V. Sinclair, , Suman Mitra

This study shows that chronic extracellular acidosis remodels lysosomes in CD8+ T cells, impairing their cytotoxicity by depleting granzyme B through vesicle release.

bioRxiv · Oct 27, 2026 · PreprintImmunology