ImmunologybioRxivPreprint
Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity
Benjamin Segain, Ryan Conesa, Christina M. Rollings…·Suman Mitra
This study shows that chronic extracellular acidosis remodels lysosomes in CD8+ T cells, impairing their cytotoxicity by depleting granzyme B through vesicle release.
DOI 10.64898/2026.10.21.760659