Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming
Michael Stock, Maria Guillen-Angel, Monika Witzenberger, Jakub Nowak, Anna Biela, Andrzej Chramiec‐Głąbik, Vittoria Mariano, René Dreos, Athéna Sklias, Manfredo Quadroni, Anneke Brümmer, Héctor Gallart‐Ayala, Julijana Ivanišević, Nicolas Guex, Leon Kleenman, , Jean‐Yves Roignant
The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.
bioRxiv · May 12, 2025 · PreprintGenetics