Claudia Bagni

This paper develops a peptidomimetic inhibitor of eIF4E that suppresses cap-dependent translation in cancer and neurodevelopmental disorders, showing efficacy in cell and animal models.

This study improves brain organoid reproducibility by reducing fluid flow shear stress through controlled culture conditions.

The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.

The paper investigates how cell-type-specific disruptions in cortico-striatal circuits in FXS model mice lead to repetitive behaviors and identifies potential therapeutic targets.

This study shows that CYFIP1 haploinsufficiency in mice causes reduced brain functional connectivity and white matter defects, linking it to neuropsychiatric disorders like Autism and Schizophrenia.