Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4'-fluorouridine
Leon Schrell, Hannah L Fuchs, Antje Dickmanns, David Scheibner, Judith Olejnik, Adam J. Hume, Wencke Reineking, Theresa Störk, Martin Müller, Annika Graaf-Rau, Sandra Diederich, Stefan Finke, Wolfgang Baumgärtner, Elke Mühlberger, Anne Balkema‐Buschmann, Matthias Dobbelstein
This paper shows that DHODH inhibitors enhance the antiviral effect of 4'-FlU against multiple RNA viruses, including influenza, SARS-CoV-2, and Ebola virus.
Antiviral Research · Dec 3, 2024Peer-reviewedMicrobiology