This paper introduces a color-neutral and reversible tissue transparency method that enables longitudinal deep-tissue imaging in live mice with high spatiotemporal resolution.

Proceedings of the National Academy of Sciences · Aug 26, 2025Peer-reviewedBioengineering

Synergistic interference with SARS-CoV-2 replication by Molnupiravir-derived N4 hydroxycytidine and inhibitors of CTP synthetase

Kim M. Stegmann, Antje Dickmanns, Hannah L Fuchs, David Scheibner, Björn-Patrick Mohl, Florian R Moeselaken, Wencke Reineking, Theresa Störk, Asisa Volz, Philip A. Beer, Andrew Parker, Veronika Pilchová, Christian Meyer zu Natrup, Maren von Köckritz-Blickwede, Wolfgang Baumgärtner, , Matthias Dobbelstein

This paper shows that combining N4-hydroxycytidine with CTP synthetase inhibitors strongly reduces SARS-CoV-2 replication in cell culture and animal models.

bioRxiv · Mar 6, 2025 · PreprintMicrobiology

Ptpn14 Knockout Mice Reveal Critical Female-Specific Roles for the Hippo Pathway

Edel M. McCrea, Neoklis Makrides, Takako Tabata, Hannes S. Vogel, Brooke E. Howitt, Wencke Reineking, José G. Vilches-Moure, Mengxiong Wang, Xin Zhang, Laura Donatella Attardi

This study shows that Ptpn14 deficiency in mice causes female-specific Hippo pathway defects, including corneal lesions, uterine defects, and organ abnormalities, with conserved roles in humans.

bioRxiv · Jan 13, 2025 · PreprintDevelopmental Biology

Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4'-fluorouridine

Leon Schrell, Hannah L Fuchs, Antje Dickmanns, David Scheibner, Judith Olejnik, Adam J. Hume, Wencke Reineking, Theresa Störk, Martin Müller, Annika Graaf-Rau, Sandra Diederich, Stefan Finke, Wolfgang Baumgärtner, Elke Mühlberger, Anne Balkema‐Buschmann, Matthias Dobbelstein

This paper shows that DHODH inhibitors enhance the antiviral effect of 4'-FlU against multiple RNA viruses, including influenza, SARS-CoV-2, and Ebola virus.

Antiviral Research · Dec 3, 2024Peer-reviewedMicrobiology