Judith Olejnik

Immunomodulatory RIG-I Agonist SLR14 Confers Protection Against a Range of Highly Pathogenic Negative Sense RNA viruses

SLR14, an immunomodulatory RIG-I agonist, provides broad-spectrum antiviral protection against multiple highly pathogenic negative-sense RNA viruses in vitro and in vivo.

Ebola virus mRNAs contain RNA structures that are critical for viral infection and targetable by antisense oligonucleotides

This study identifies RNA structures in Ebola virus mRNAs critical for infection and shows they can be targeted by antisense oligonucleotides.

Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4'-fluorouridine

This paper shows that DHODH inhibitors enhance the antiviral effect of 4'-FlU against multiple RNA viruses, including influenza, SARS-CoV-2, and Ebola virus.

Minor intron containing genes: Achilles' heel of viruses?

The paper identifies MIG-encoded proteins as potential pan-viral drug targets, showing that repurposed anti-cancer drugs target these proteins.

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

This study uses human stem cell-derived alveolar type 2 cells to model SARS-CoV-2 infection, revealing rapid inflammatory responses and drug efficacy against the virus.