DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
Jennifer Porat, Valentina Poli, Karim Almahayni, Benson M. George, Francisca N. de Luna Vitorino, Li Yi, Carolina Bras Costa, Yitong Zhou, Andrew Crompton, Hongxiu Wen, Leon Zheng, Peter K. Gregersen, Suneet Agarwal, Benjamin A. Garcia, Yixuan Xie, , Ryan A. Flynn
This study shows DNASE1L3 clears surface DNA on B and T cells, and variants in DNASE1L3 are linked to higher surface DNA levels in autoimmune disease.
bioRxiv · Oct 5, 2025 · PreprintCell Biology