Yixuan Xie

Metabolically encoded cell-surface glycoRNA remodeling enhances antitumor immunity

This study shows that tumor cells remodel cell-surface glycoRNA through metabolic reprogramming, impairing immune responses and linking glycoRNA to antitumor immunity and tumor progression.

Lysosomal Aspartylglucosaminidase Couples Glycoprotein Catabolism to Cell-Surface GlycoRNA Production

The paper identifies lysosomal aspartylglucosaminidase (AGA) as a rate-limiting regulator linking glycoprotein catabolism to glycoRNA formation.

Chromatin context-dependent deacetylation by the asymmetric Rpd3L

This study reveals how the Rpd3L complex uses an asymmetric architecture to activate deacetylation in response to chromatin context.

Nuclear N-Glycosylation Redefines the Glycoscape and Directs Cell Identity

The paper identifies nuclear N-glycosylation as a novel modification that influences cell identity and is linked to neurodevelopmental disorders.

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

This study shows DNASE1L3 clears surface DNA on B and T cells, and variants in DNASE1L3 are linked to higher surface DNA levels in autoimmune disease.

An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling

The paper introduces an unbiased proteomic platform for ATE1-based arginylation profiling, identifying 235 unique arginylation sites in human proteomes.

StCEL-based platform enables detection and sequencing of native sialoglycoRNA

The paper introduces StCEL, a method for detecting and sequencing native sialoglycoRNA, showing its upregulation in cancers and correlation with poor prognosis.

Development and application of GlycanDIA workflow for glycomic analysis

The paper develops GlycanDIA, a DIA-based workflow for glycan identification and quantification, showing improved sensitivity and the ability to detect low-abundant modified glycans.

Metabolic Control of Glycosylation Forms for Establishing Glycan-Dependent Protein Interaction Networks

The paper introduces GAP-MS to study glycan-dependent PPIs and shows it identifies PPI variations under different glycosylation conditions.

The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA

The paper identifies acp3U as the site where N-glycans attach to RNA in glycoRNA using rPAL and SWATH-MS.

The N-Glycome regulates the endothelial-to-hematopoietic transition

The paper shows that N-glycan modifications regulate endothelial-to-hematopoietic transition by affecting glycosylation enzymes and HSPC production.