Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases
Leonardo Diaz, Ally Xinyi Kong, Ping Zhang, Jinhua Chi, Khoa Trong Pham, Maja Johnson, Aiden F Eno, Isabelle Douglas, Yuxuan Mao, James W. MacDonald, Julia Yue Cui, Theo K. Bammler, Haiwei Gu, Yijie Geng
The paper shows that butyrate rescues CPF-induced social deficits in zebrafish by inhibiting class I HDACs, linking CPF exposure to gut microbiome, metabolome, and epigenetic changes.
bioRxiv · Oct 19, 2025 · PreprintNeuroscience