Evolutionary algorithms accelerate de novo design of potent Nectin-4-specific cancer biologics
Elisabeth Tan, Sophie C Frechen, Bianca Broske, Julia M. Messmer, Tim Noah Kempchen, Benjamin A. McEnroe, Dominic Ferber, Leonie Waluga, Eduard Below, Alexander Hoch, Michelle C.R. Yong, Johannes Oldenburg, Heiko Rühl, Matthias Geyer, Marieta Ioana Toma, , Gregor Hagelueken
This paper combines evolutionary algorithms with AI to design potent Nectin-4-specific cancer biologics, achieving high-affinity minibinders and functional reagents.
bioRxiv · Mar 6, 2026 · PreprintBioengineering