Dominic Ferber

This paper combines evolutionary algorithms with AI to design potent Nectin-4-specific cancer biologics, achieving high-affinity minibinders and functional reagents.

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

This paper develops AI-designed protein binders for cancer cell surface proteins, showing their effectiveness in detection and targeting through experimental validation and benchmarking of structure prediction models.