Author

Alexander Hoch

University of BonnORCID 0000-0002-4790-5507Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jonathan Leo Schmid-BurgkiD· 4 shared Caroline I. FandreyiD· 3 shared Gregor HageluekeniD· 3 shared Michael HölzeliD· 3 shared Tim Noah KempcheniD· 3 shared Benjamin A. McEnroeiD· 2 shared Bianca BroskeiD· 2 shared Dominic FerberiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

Jonathan Leo Schmid-BurgkORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Evolutionary algorithms accelerate de novo design of potent Nectin-4-specific cancer biologics

Elisabeth Tan, Sophie C Frechen, Bianca Broske, Julia M. Messmer, Tim Noah Kempchen, Benjamin A. McEnroe, Dominic Ferber, Leonie Waluga, Eduard Below, Alexander Hoch, Michelle C.R. Yong, Johannes Oldenburg, Heiko Rühl, Matthias Geyer, Marieta Ioana Toma, , Gregor Hagelueken

This paper combines evolutionary algorithms with AI to design potent Nectin-4-specific cancer biologics, achieving high-affinity minibinders and functional reagents.

bioRxiv · Mar 6, 2026 · PreprintBioengineering

Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells

Alexander Hoch, Caroline I. Fandrey, Brian Coventry, Sebastian Virreira Winter, Philipp Emanuel Geyer, Tim Noah Kempchen, Thomas S. Ebert, Michael Hölzel, David A. Baker, Jonathan Leo Schmid-Burgk

This paper introduces Transposon-Display, a method to identify and optimize AI-designed protein binders for intracellular use, enabling controlled protein manipulation in human cells.

bioRxiv · May 11, 2025 · PreprintBioengineering

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

Bianca Broske, Sophie C. Binder, Benjamin A. McEnroe, Tim Noah Kempchen, Caroline I. Fandrey, Julia M. Messmer, Elisabeth Tan, Peter Konopka, Dominic Ferber, Michelle C.R. Yong, Marie Kleinert, Alexander Hoch, Katja Blumenstock, Jan M. P. Tödtmann, Johannes Oldenburg, , Michael Hölzel

This paper develops AI-designed protein binders for cancer cell surface proteins, showing their effectiveness in detection and targeting through experimental validation and benchmarking of structure prediction models.

bioRxiv · May 11, 2025 · PreprintBioengineering

Sensing endogenous RNA in living human cells using a CRISPR-activated protease

Katja Blumenstock, Alexander Hoch, Leo Daniel Hinterlang, Caroline I. Fandrey, Niels Schneberger, Gregor Hagelueken, Jonathan Leo Schmid-Burgk

This paper introduces CRISPR-READ, a live cell RNA sensor that detects endogenous transcripts and identifies Type-I interferon signaling through RNA-seq of sorted cells.

bioRxiv · Jul 17, 2024 · PreprintBioengineering