Author

Leslie Grimmett

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Annette S. KimiD· 2 shared Harrison Kwei TsaiiD· 2 shared Marian H. HarrisiD· 2 shared Valentina NardiiD· 2 shared Adam S. FischiD· 1 shared Allison F. Gillaspy· 1 shared Andrew E. PlaceiD· 1 shared Arnaldo ArbiniiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Annette S. KimORCID

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Author profile →

3 papers

Recent·Most cited

Acute promyelocytic leukemia with torque teno mini virus (TTMV)::RARA fusion: an approach to screening and diagnosis

Harrison Kwei Tsai, Mark F Sabbagh, Meagan Montesion, Erik Abraham Williams, Arnaldo Arbini, Daniel R. Boué, Emily M. Harris, Franziska Wachter, Leslie Grimmett, Andrew E. Place, Fabienne McClanahan Lucas, Valentina Nardi, Annette S. Kim, Carlo Brugnara, Barbara A. Degar, , Jacob R. Bledsoe

The paper describes a clinicopathologic approach and tools for diagnosing APL with TTMV::RARA fusion using NGS assays, identifying four cases with poor treatment outcomes.

medRxiv · Mar 29, 2024 · PreprintGenetic & Genomic Medicine

Outlier expression of isoforms by targeted RNA sequencing as clinical markers of genomic variants in B lymphoblastic leukemia and other tumor types

Harrison Kwei Tsai, Tasos Gogakos, Va Lip, Jonathan M. Tsai, Yen-Der Li, Adam S. Fisch, Jonathan Weiss, Leslie Grimmett, Thai Hoa Tran, Maxime Caron, Sylvie Langlois, Daniel Sinnett, Yana Pikman, Annette S. Kim, Valentina Nardi, , Marian H. Harris

The paper identifies outlier RNA isoform expression as a method to detect clinically relevant genomic variants in B-ALL and other cancers with high sensitivity and specificity.

medRxiv · Jul 29, 2022 · PreprintGenetic & Genomic Medicine

Cross-Site Comparison of Ribosomal Depletion Kits for Illumina RNAseq Library Construction

Zachary T. Herbert, Jamie P. Kershner, Vincent L. Butty, Jyothi Thimmapuram, Sulbha Choudhari, Yuriy O. Alekseyev, Jun Fan, Jessica W. Podnar, Edward Wilcox, Jenny R. Gipson, Allison F. Gillaspy, Kristen Jepsen, Sandra Splinter BonDurant, Krystalynne Morris, Maura Berkeley, , Stuart S. Levine

The paper compares ribosomal depletion kits for RNAseq library construction, finding differences in ease of use and transcript length impact on library efficiency.

BMC Genomics · Mar 15, 2018Peer-reviewedGenomics