Maxime Caron

EpiATLAS - a reference for human epigenomic research

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

Outlier expression of isoforms by targeted RNA sequencing as clinical markers of genomic variants in B lymphoblastic leukemia and other tumor types

The paper identifies outlier RNA isoform expression as a method to detect clinically relevant genomic variants in B-ALL and other cancers with high sensitivity and specificity.

Real-time molecular classification of leukemias

This study demonstrates real-time transcriptomic profiling using nanopore sequencing and a neural network classifier to classify childhood acute lymphoblastic leukemia subtypes efficiently.

Pre-Implantation Alcohol Exposure Induces Lasting Sex-Specific DNA Methylation Programming Errors in the Developing Forebrain

This study shows that pre-implantation alcohol exposure causes sex-specific DNA methylation errors in fetal mouse forebrains, potentially contributing to FASD-related neurodevelopmental issues.

Developmental Genome-Wide DNA Methylation Asymmetry Between Mouse Placenta and Embryo

The paper investigates DNA methylation asymmetry between mouse placenta and embryo, identifying DMR subtypes and the role of DNMT3B and DNMT3A in establishing and maintaining these patterns.

GenPipes: an open-source framework for distributed and scalable genomic analyses

GenPipes provides a scalable framework for genomic analyses, offering pre-built pipelines and flexibility for custom workflows.