Author

Leslie S. Chao

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alexander M. LoibeniD· 3 shared Charles E. MurryiD· 3 shared Clayton E. FriedmaniD· 3 shared Kai‐Chun YangiD· 3 shared Wei‐Ming ChieniD· 3 shared Ashley MckinstryiD· 2 shared Dania Ahmed· 2 shared Douglas M. FowleriD· 2 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Alexander M. LoibenORCID

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Author profile →

3 papers

Recent·Most cited

Multiplexed functional assessments of MYH7 variants in human cardiomyocytes at scale

Clayton E. Friedman, Shawn Fayer, Sriram Pendyala, Wei‐Ming Chien, Linda N. Tran, Leslie S. Chao, Ashley Mckinstry, Dania Ahmed, Alexander M. Loiben, Stephen D. Farris, April Stempien‐Otero, Erica C. Jonlin, Charles E. Murry, Lea M. Starita, Douglas M. Fowler, Kai‐Chun Yang

This study uses hiPSC-derived cardiomyocytes to assess MYH7 variants' effects, showing pathogenic variants reduce protein abundance and cell survival.

bioRxiv · Jul 28, 2023 · PreprintGenetics

CRaTER enrichment for on-target gene-editing enables generation of variant libraries in hiPSCs

Clayton E. Friedman, Shawn Fayer, Sriram Pendyala, Wei‐Ming Chien, Alexander M. Loiben, Linda N. Tran, Leslie S. Chao, Ashley Mckinstry, Dania Ahmed, Elaheh Karbassi, Aidan M. Fenix, Charles E. Murry, Lea M. Starita, Douglas M. Fowler, Kai‐Chun Yang

CRaTER enriches for on-target gene-edited cells in hiPSCs, enabling efficient generation of variant libraries for studying cardiomyopathy-associated mutations.

Journal of Molecular and Cellular Cardiology · Apr 3, 2023Peer-reviewedGenetics

Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopa-thy

Alexander M. Loiben, Wei‐Ming Chien, Clayton E. Friedman, Leslie S. Chao, Gerhard Weber, Alex J. Goldstein, Nathan J. Sniadecki, Charles E. Murry, Kai‐Chun Yang

This study shows that MYH7 E848G mutation causes cardiomyocyte apoptosis and contractile dysfunction in a stem cell model of HCM, independent of p53.

bioRxiv · Jan 24, 2023 · PreprintMolecular Biology