Transcriptional control of central T cell tolerance by NR4A family nuclear receptors
Hailyn V. Nielsen, Letitia Yang, James L. Mueller, Alexander J. Ritter, Ryosuke Hiwa, Irina Proekt, Elze Rackaityte, Dominik A. Aylard, Mansi Gupta, Christopher D. Scharer, Mark Stuart Anderson, Byron B. Au‐Yeung, Julie Zikherman
This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.
Nature Communications · Jan 17, 2025Peer-reviewedImmunology