Ancient IL-6-STAT5 signaling orchestrates inflammation in jawless vertebrates
Francisco Fontenla-Iglesias, Jean‐Louis Boulay, Jonathan P. Rast, Masayuki Hirano, Byron B. Au‐Yeung, Jesús Lamas, Weiming Li, Thomas L. J. Boehm, Max D. Cooper, Sabyasachi Das
This study identifies IL-6-like genes in jawless vertebrates and shows their role in inflammation through STAT5 signaling and SOCS gene regulation.
bioRxiv · Apr 6, 2026 · PreprintImmunology