Author

James L. Mueller

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander J. RitteriD· 2 shared Julie ZikhermaniD· 2 shared Alexander R. MeyeriD· 1 shared Byron B. Au‐YeungiD· 1 shared Christopher D. SchareriD· 1 shared Dominik A. AylardiD· 1 shared Elze RackaityteiD· 1 shared Erika Kay-TsumagariiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Alexander J. RitterORCID

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2 papers

Recent·Most cited

Virus-like antigen display delivers a stand-alone danger signal through the BCR that circumvents tolerance

Julianne B. Riggs, Alexander J. Ritter, François X. P. Bourassa, Alexander R. Meyer, Erika Kay-Tsumagari, Wei-Yun Wholey, Jeremy B. Libang, James L. Mueller, Wen Lu, Ned S. Wingreen, Wei Cheng, Julie Zikherman

The paper shows that virus-like particle-displayed antigens bypass BCR tolerance by triggering distinct signaling and transcriptional programs compared to soluble antigens.

bioRxiv · Apr 24, 2026 · PreprintImmunology

Transcriptional control of central T cell tolerance by NR4A family nuclear receptors

Hailyn V. Nielsen, Letitia Yang, James L. Mueller, Alexander J. Ritter, Ryosuke Hiwa, Irina Proekt, Elze Rackaityte, Dominik A. Aylard, Mansi Gupta, Christopher D. Scharer, Mark Stuart Anderson, Byron B. Au‐Yeung, Julie Zikherman

This study identifies the role of Nr4a family nuclear receptors in transcriptional control of T cell tolerance during thymic development, showing their necessity for negative selection and anergy-like programs in self-reactive T cells.

Nature Communications · Jan 17, 2025Peer-reviewedImmunology