Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in Mycobacterium abscessus
Shuai Wang, Md Shah Alam, Buhari Yusuf, Jingran Zhang, Ziwen Lu, Xiaofan Zhang, H. M. Adnan Hameed, Mst Sumaia Khatun, Chunyu Li, Lijie Li, Aleksey A. Vatlin, Aweke Mulu Belachew, Xirong Tian, Yamin Gao, Cuiting Fang, , Tianyu Zhang
This study identifies homologous recombination as a key mechanism of fluoroquinolone resistance in Mycobacterium abscessus and shows that targeting HR enhances FQ efficacy in vitro and in vivo.
mLife · Sep 22, 2026Peer-reviewedMolecular Biology