Tianyu Zhang

This study identifies homologous recombination as a key mechanism of fluoroquinolone resistance in Mycobacterium abscessus and shows that targeting HR enhances FQ efficacy in vitro and in vivo.

This study identifies EthR and EthA genes in Mycobacterium abscessus that mediate resistance to ethionamide, showing EthR is a more dominant resistance factor than NudC.

This study identifies SigH as a key regulator of intrinsic antibiotic resistance in Mycobacterium abscessus through transcriptomic analysis and genetic complementation.

This study identifies a synonymous mutation in MSMEG_4729 that frequently occurs in D29-resistant mutants of Mycobacterium smegmatis and links it to potential resistance mechanisms involving LOS biosynthesis and m6A modifications.

This study identifies promoter reconstitution via IS6120 insertion upstream of mpr as the mechanism behind Mpr overexpression in D29-resistant M. smegmatis mutants.

This study identifies MAB_2363 as a division-associated protein that contributes to intrinsic resistance and virulence in Mycobacterium abscessus by affecting cell division and antibiotic susceptibility.

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

This paper introduces a CRISPR-NHEJ strategy for efficient gene disruption in Mycobacterium abscessus and shows that homologous recombination and single-strand annealing components are required for NHEJ repair.

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.

This paper develops an autoluminescent model to assess anti-tuberculosis drugs against nonreplicating M. tuberculosis, showing real-time light output correlates with colony-forming units and reveals drug efficacy differences under anaerobic vs aerobic conditions.

The paper introduces a novel algorithm to improve Hi-C contact matrices by inferring linear genomes from Hi-C data using genome graphs, resulting in more accurate structural representations.