Cuiting Fang

Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in Mycobacterium abscessus

This study identifies homologous recombination as a key mechanism of fluoroquinolone resistance in Mycobacterium abscessus and shows that targeting HR enhances FQ efficacy in vitro and in vivo.

Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide

This study identifies EthR and EthA genes in Mycobacterium abscessus that mediate resistance to ethionamide, showing EthR is a more dominant resistance factor than NudC.

The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in Mycobacterium abscessus

This study identifies SigH as a key regulator of intrinsic antibiotic resistance in Mycobacterium abscessus through transcriptomic analysis and genetic complementation.

Discovery of ARQ-501 as a potent PafA inhibitor that elevates KatG levels to potentiate isoniazid in mycobacteria

The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.

A synonymous mutation in MSMEG_4729 occurs at a high frequency in spontaneous D29-resistant mutants of Mycobacterium smegmatis

This study identifies a synonymous mutation in MSMEG_4729 that frequently occurs in D29-resistant mutants of Mycobacterium smegmatis and links it to potential resistance mechanisms involving LOS biosynthesis and m6A modifications.

Likely role of promoter reconstitution in Mpr-mediated D29 resistance by Mycobacterium smegmatis

This study identifies promoter reconstitution via IS6120 insertion upstream of mpr as the mechanism behind Mpr overexpression in D29-resistant M. smegmatis mutants.

A division-associated envelope protein, MAB_2363, drives intrinsic resistance and virulence in Mycobacterium abscessus

This study identifies MAB_2363 as a division-associated protein that contributes to intrinsic resistance and virulence in Mycobacterium abscessus by affecting cell division and antibiotic susceptibility.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.