Xinyue Wang

This study identifies homologous recombination as a key mechanism of fluoroquinolone resistance in Mycobacterium abscessus and shows that targeting HR enhances FQ efficacy in vitro and in vivo.

This study identifies EthR and EthA genes in Mycobacterium abscessus that mediate resistance to ethionamide, showing EthR is a more dominant resistance factor than NudC.

This study identifies a synonymous mutation in MSMEG_4729 that frequently occurs in D29-resistant mutants of Mycobacterium smegmatis and links it to potential resistance mechanisms involving LOS biosynthesis and m6A modifications.

The paper introduces novel far-red fluorescent proteins for temporal domain multiplexing and super-resolution imaging, enabling subcellular structure distinction without hardware modifications.

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

The paper uses proteomic analysis to study HCMV-infected dendritic cells, revealing how the virus manipulates adaptive immunity and restricts replication.

This paper develops an autoluminescent model to assess anti-tuberculosis drugs against nonreplicating M. tuberculosis, showing real-time light output correlates with colony-forming units and reveals drug efficacy differences under anaerobic vs aerobic conditions.