Author

Li Wen

Chinese Academy of Medical Sciences & Peking Union Medical College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Biao Ma· 1 shared Bin XiaoiD· 1 shared Chenglong MuiD· 1 shared Chuanmei ZhangiD· 1 shared Fangze Qian· 1 shared Gao WentaoiD· 1 shared Guangfeng GengiD· 1 shared Han LiangiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Biao Ma

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Co-evolution of Oncogenic KRAS Signaling and LILRBhigh Macrophages Drives Pancreatic Cancer Recurrence

Jianzhen Lin, Zhenzhen Xun, Fangze Qian, Zhigao Chen, Weikang Hu, W. Liu, Yang Wu, Hao Yuan, Lingdi Yin, Yuxing Wang, Xiao Huang, Yujia Dang, Bin Xiao, Junli Wu, Gao Wentao, , Han Liang

This study identifies a co-evolved tumor-immune interaction involving KRAS signaling and LILRBhigh macrophages that drives PDAC recurrence and presents a therapeutic strategy targeting this axis.

bioRxiv · Mar 7, 2026 · PreprintCancer Biology

RNA localization to nuclear speckles follows splicing logic

Li Wen, Mauricio A. Arias, Xinqi Fan, Joyce Xie, S. Titus Paul, Susan E. Liao, Marek Sobczyk, Oded Regev, Jingyi Fei

This study identifies sequence features that determine RNA localization to nuclear speckles, showing similarities with splicing codes and linking speckle localization to spliceosome assembly and splicing efficiency.

Nucleic Acids Research · Feb 18, 2026Peer-reviewedBiochemistry

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

Chenglong Mu, Biao Ma, Chuanmei Zhang, Guangfeng Geng, Xinling Zhang, Linbo Chen, Meng Wang, Jie Li, Tian Zhao, Hongcheng Cheng, Qianping Zhang, Kaili Ma, Qian Luo, Rui Chang, Qiangqiang Liu, , Yushan Zhu

This study shows that SDHB deficiency reprograms energy metabolism and protects against high fat diet-induced obesity by restoring glucose and lipid metabolism.

bioRxiv · Feb 3, 2018 · PreprintMolecular Biology