Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cells
Kelly McCastlain, Catherine E. Welsh, Yonghui Ni, Liang Ding, Melissa Franco, Robert J. Autry, Besian I. Sejdiu, Ti‐Cheng Chang, Wenan Chen, Huiyun Wu, Qingfei Pan, Veronica Gonzalez-Pena, Patrick A. Schreiner, Sasi Arunachalam, Joung Hyuck Joo, , Mondira Kundu
The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.
medRxiv · Sep 26, 2024 · PreprintGenetic & Genomic Medicine