Huiyun Wu

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

This study shows that somatic mtDNA mutations affect metabolic plasticity in leukemia development, with heterozygous mutations supporting NMyc-driven leukemia while homozygous mutations impair it.

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.