Compressive stress couples calcium signalling to translational control and proteostasis
Giuseppe Fragale, Benjamin J. Hershey, Yuwei Li, Giorgia Parodi, Galina V. Beznoussenko, Elisa Allievi, Arta Ajazi, Nicol Berti, Wanxin Zheng, Zeno Lavagnino, Vittoria Matafora, Federica Pisati, Nicola Manfrini, Stefano Biffo, Ligia Martinez, , Kristina M. Havas
This study shows compressive stress activates a calcium-dependent pathway that reduces translation and proteostasis through multiple mechanisms, correlating with poor survival in pancreatic cancer.
bioRxiv · Oct 9, 2026 · PreprintCell Biology