Spatial organization of pulmonary type 2 inflammation by a macrophage-derived cholesterol metabolite
Yufan Zheng, Hannah E. Dobson, Makheni Jean Pierre, Lilly LeBlanc, Chinaemerem U. Onyishi, Dominic P. Golec, Nathan Carrillo, Anshu Deewan, Claudia A. Rivera, Eduard Ansaldo, Eric V. Dang
The paper identifies a cholesterol metabolite that spatially organizes TH2 cells during fungal-induced pulmonary inflammation, promoting fungal persistence and suppressing interferon-gamma responses.
bioRxiv · Jul 29, 2025 · PreprintImmunology