Eric V. Dang

The paper uses single-cell RNA sequencing to show that Th1-like CD4 T-cells with CTLA-4 expression control latent C. neoformans infection, and CTLA-4 suppression of Th2 activation is beneficial.

This study identifies alternatively activated myeloid cells as drivers of extracellular fungal persistence in pulmonary granulomas through T helper 2 cell signaling.

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

The paper identifies a cholesterol metabolite that spatially organizes TH2 cells during fungal-induced pulmonary inflammation, promoting fungal persistence and suppressing interferon-gamma responses.

This paper describes a method to efficiently generate genetically modified primary human myeloid cells using CRISPR-Cas9 RNP nucleofection, demonstrating its utility in studying HIV-1 infection and myeloid cell biology.