Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred C. elegans mutation accumulation lines
Timothy A. Crombie, Moein Rajaei, Ayush S. Saxena, Lindsay Johnson, Sayran Saber, Robyn E. Tanny, José Miguel Ponciano, Erik C. Andersen, Juannan Zhou, Charles F. Baer
This study infers the distribution of fitness effects of mutations in C. elegans using recombinant inbred lines, finding that positive effects are common but LD can skew results.
Genetics · Aug 14, 2024Peer-reviewedEvolutionary Biology