Timothy A. Crombie

Global genomic diversity of the selfing nematode Caenorhabditis tropicalis correlates with geography

The paper analyzes the genomic diversity of C. tropicalis, finding geographic correlation and hyper-divergent regions linked to environmental adaptation.

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants

The paper identifies 94 candidate genes in C. elegans linked to susceptibility to 23 environmental toxicants using genome-wide association analysis.

Caenorhabditis briggsae ancestral genomic hyper-diversity contrasts with globally distributed genome-wide haplotypes

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred C. elegans mutation accumulation lines

This study infers the distribution of fitness effects of mutations in C. elegans using recombinant inbred lines, finding that positive effects are common but LD can skew results.

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans strains

This study identifies genetic differences among C. elegans strains that drive variation in anthelmintic responses across multiple drug classes, highlighting the importance of genetic diversity in understanding anthelmintic resistance.

An automated approach to quantify chemotaxis index in Caenorhabditis nematodes

This paper introduces an automated method for quantifying chemotaxis index in C. elegans using liquid-handling robots and a custom image analysis tool.

easyXpress: An R package to analyze and visualize high-throughput C. elegans microscopy data generated using CellProfiler

easyXpress is an R package for analyzing and visualizing high-throughput C. elegans microscopy data from CellProfiler, offering customizable filtering and interactive visualization tools.

Natural variation in arsenic toxicity is explained by differences in branched chain amino acid catabolism

This study identifies a genetic variant in C. elegans that affects arsenic toxicity through differences in branched-chain amino acid metabolism.