Robyn E. Tanny

Tools for genetic mapping and gene identification in Caenorhabditis briggsae

The paper updates a toolkit for genetic studies in C. briggsae by identifying indel variants and mapping mutations to genes using high-throughput sequencing.

Selfing-aware demographic inference highlights local population structure and bottlenecks in Hawaiian Caenorhabditis elegans

The paper applies a selfing-aware demographic inference method to Hawaiian C. elegans populations, revealing population structure, bottlenecks, and the impact of self-fertilization on demographic estimates.

Global genomic diversity of the selfing nematode Caenorhabditis tropicalis correlates with geography

The paper analyzes the genomic diversity of C. tropicalis, finding geographic correlation and hyper-divergent regions linked to environmental adaptation.

A gap-free, telomere-to-telomere genome assembly for the Caenorhabditis briggsae reference strain AF16

The paper presents a gap-free, telomere-to-telomere genome assembly for the C. briggsae AF16 strain, along with improved gene annotations and variant mappings.

Evolution of the rate, spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans

This study tracks mutation rates and fitness effects in C. elegans under minimal selection, finding increased indel mutation rates and no change in nucleotide substitution rates.

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants

The paper identifies 94 candidate genes in C. elegans linked to susceptibility to 23 environmental toxicants using genome-wide association analysis.

Mutational divergence over years in local populations of the selfing nematode Caenorhabditis elegans

The paper tracks mutation accumulation in natural C. elegans populations over time, finding a substitution rate and spatio-temporal dispersal patterns.

Caenorhabditis briggsae ancestral genomic hyper-diversity contrasts with globally distributed genome-wide haplotypes

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred C. elegans mutation accumulation lines

This study infers the distribution of fitness effects of mutations in C. elegans using recombinant inbred lines, finding that positive effects are common but LD can skew results.

Natural variation in the irld gene family affects starvation resistance in C. elegans

The paper identifies natural variation in the irld gene family affecting starvation resistance in C. elegans using MIP-seq and genome-wide association.

Chromosome-level reference genomes for two strains of Caenorhabditis briggsae: an improved platform for comparative genomics

The paper generates chromosome-level reference genomes for two C. briggsae strains, improving genomic resources for comparative genomics in the Caenorhabditis genus.

Two novel loci underlie natural differences in Caenorhabditis elegans macrocyclic lactone responses

The paper identifies three genomic regions in C. elegans associated with natural variation in macrocyclic lactone response, including two novel loci and one previously known locus.

Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans

The paper identifies a gene, sqst-5, associated with zinc resistance in C. elegans by analyzing genetic variation between strains with different zinc responses.

Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model

The paper identifies genetic modifiers of propionate sensitivity in C. elegans using genome-wide association mapping and shows that natural variation in GLCT-3 modulates this trait.

Population selection and sequencing of C. elegans wild isolates identifies a region on chromosome III affecting starvation resistance

A nematode-specific gene underlies bleomycin-response variation in Caenorhabditis elegans

This study identifies a nematode-specific gene, scb-1, as a genetic determinant of bleomycin-response variation in C. elegans using linkage mapping and CRISPR-Cas9 experiments.

Common genomic regions underlie natural variation in diverse toxin responses

The paper identifies QTL underlying toxin response variation in C. elegans and validates their contributions through experimental assays.